I have / had the smaller version of that, I put some wrenches and a 3/4 impact gun in the bottom drawer and it folded up like alumnium foil ;P
It's cheaper because it's lighter because the sheet metal is thinner, if you are ok with lightly loading it, it's pretty tho :)
110V mig machines in general often have issues because of the limited amount of power available to the machine, if you *must* have a portable machine you can plug in at your buddy's house with no 220v outlet, it's what you are stuck with, but otherwise, it's worth swinging for the 220v machine....
It's not just about the weight ;P it's also about the wire feeder, the wire feed mechanism is what made miller :)
Sure a good welder can cope with anything, but who wants to spend 75% of their welding time futzing with the feed mechanism......
(Is it just me, or does that machine look just like the Home Depot Lincoln machines?)