I have not sold anything that couldn't fit in one of the flat rate boxes or other boxes in a long time. I am trying to find the best way to ship a box 22 1/2 x 11 1/2 x 12 1/2 weighing 18 pounds. Seems the mailing cost is quite high. Waiting for an estimate from Fastenal as an alternative to USPS or UPS.

Anyone know more about this ?

Also try FedEx.

Stuff it with worthless old books and ship it book rate. 

That may work ! I have never shipped with them, though I have gotten packages delivered here by them.

Maybe you have a friend who has access to a shipping account at their work.  Businesses with UPS accounts get a discounted rate.  It's not an outlandish package size so it would not be difficult to handle. 
I have been using UPS for those size packages.  There's a UPS store with good customer service just a few minutes from my work.
Al

Quotes online from UPS and FedX are way too high. I can try the local UPS shipping store.

i found independently owned ups the worst,on ebay i use fedex for bigger stuff,at good $$,no complaints on estimated cost,shipped a few wooden machinist tool boxes..........

 Don't know if you have access to a greyhound stop but how about a bus ride for the box?

If you check FedEx be sure to select FedEx Ground. Worst case it takes a couple extra days to arrive but it is significantly cheaper than regular FedEx or UPS in my experience.

AARP if you are a member will get you some kind of discount at UPS stores but I don't know how much.

I am no longer  a member of AARP, and won't be again ever. It is a political thing, so I won't discuss it further.

US postal service " ground" is as cheap as you will find

My local UPS store will deliver it to the door for $40. I will do that. Thanks all for your input.

I shipped a mini-mite muller to Maine from the St.Louis area thru Fastenal. about 3' cube, made a pallet and wooden enclosure. Approximate weight was 150# They did not weight it. It was around a 100$ it got there in 5 days on a holiday weekend and it got there in one piece!  I can highly recommend shipping a crated item.

+1 fastenal

for big heavy things

Fastenal's quote was $9 cheaper, but I was not sure the buyer had one near enough to drive to easily.